ANNEXA-4 Investigators. Anticoagulant therapy is essential to prevent thromboembolism, especially in patients who are undergoing percutaneous coronary intervention (PCI).1 Taking the effect of anticoagulant strategies into account, anticoagulant agents can be divided into two categories, one of which is anticoagulant agents, such as unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), fondaparinux and bivalirudin, which are mainly used in the perioperative period of a PCI to prevent ischemic events, including stent thromb… 34. et al. Genetic factors can predispose patients to reduced vitamin K antagonist requirements, as well as resistance. Compared with vitamin K antagonists and with other direct oral anticoagulants, apixaban (Eliquis) has less major bleeding. In patients with ACS (NSTE-ACS or STEMI) being treated with DAPT who undergo coronary artery bypass grafting (CABG), P2Y 12 inhibitor therapy should be resumed after CABG to complete 12 months of DAPT therapy after ACS (Class I). Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. Data Sources: A PubMed search was completed in Clinical Queries using the key terms outpatient, anticoagulation, warfarin, dabigatran, rivaroxaban, apixaban, edoxaban, betrixaban, heparin, low-molecular-weight heparin, dalteparin, enoxaparin, patient self-monitor, and INR. Real-world use of apixaban for stroke prevention in atrial fibrillation: a systematic review and meta-analysis. Braunwald E, et al. Grade A recommendations are supported by high-quality evidence, grade B recommendations are based on randomized clinical trials with methodologic flaws or inconsistent results, and grade C recommendations are based on weaker evidence. et al. Ezekowitz MD, Contact Patients with a history of myocardial infarction and left ventricular dysfunction are also recommended for beta-blocker therapy. et al. Pollack CV Jr, Jurk K, ; Outpatient management of anticoagulation therapy. Vitamin K antagonists inhibit the production of vitamin K-related factors and require a minimum of five days overlap with parenteral anticoagulants, whereas direct oral anticoagulants directly inhibit factor II or factor Xa, providing more immediate anticoagulation. Savaysa (edoxaban) tablets, for oral use [prescribing information]. Mentias A, Mahaffey KW, Foods with high vitamin K concentrations, such as leafy green vegetables, have the potential to partially reverse anticoagulation effects of the vitamin K antagonist.4 A consistent diet is more important than limiting dietary vitamin K. Considerations for parenteral medications are provided in eTable A. Dalteparin (Fragmin) and enoxaparin (Lovenox) are commonly used LMWHs in clinical practice. 28. et al. Patients, who are randomized to the control arm and develop recurrent AF after 30 days, may be crossed-over to an OAC. et al. Young AM, Schinzel H. ; Accrual is expected to take 36 months. ; First episode of proximal DVT or PE attributed to reversible risk factor or surgery: Three months recommended over short-term use (grade 1B), longer use (grade 1B), or extended therapy (grade 1B). American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy, Usual dosage (assess renal function before beginning direct oral anticoagulant and as clinically indicated)*. et al. Ruff CT, Evidence-based adjustment of warfarin (Coumadin) doses. Given the high rates of depression after surgery, it is reasonable to screen for depression after CABG. Process to optimize effectiveness and minimize adverse effects periprocedural or Bridging anticoagulation – administration of short. 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